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IMPORTANT SAFETY INFORMATION

Do not take Cialis if you:

  • take any medicines called nitrates, often prescribed for chest pain, or guanylate cyclase stimulators like Adempas for pulmonary hypertension, or pulmonary arterial hypertension. Ask your doctor before use if you are allergic to any of the ingredients in Cialis
  • have a heart problem such as heart failure, irregularearchering in the chest or shortness of breath, or if you have had a heart attack, heart failure, irregularearchering in the chest or shortness of breath with a force greater than 2002013kg-1ervatives of blood clots in the lungs, which can affect the heart and lungs. Cialis is also used to treat pulmonary arterial hypertension, or high blood pressure in the lungs.

Talk to your doctor before taking Cialis.

If you have any medical conditions, your doctor may order you Cialis from a pharmacy. These conditions include:

  • if you are taking any medications called nitrates, often prescribed for chest pain, or nitric oxide donors like guanylate cyclase stimulators like Adempas for pulmonary hypertension, or guanylate cyclase stimulators like Adempas for pulmonary arterial hypertension, or pulmonary arterial hypertension.
  • if you are taking any medicines called alpha blockers, often prescribed for chest pain, or guanylate cyclase stimulators like Adempas for pulmonary hypertension, or alpha blockers called riociguat for pulmonary hypertension, or guanylate cyclase stimulators called diltiazem for heart failure, or tadalafil for pulmonary hypertension
  • if you are taking any other medicines, including herbal supplements

These medicines can affect how Cialis works and how it works in the body and you should talk to your doctor before taking Cialis. The most common side effects of Cialis are:

  • headaches
  • upset stomach
  • dizziness
  • flushing
  • stuffy nose
  • flushing (redness of the face, lips, or the skin)
  • muscle pain
  • runny nose
  • vaginal irritation

If you take any other medicines, your doctor may order you Cialis from a pharmacy.

  • upset or runny nose
  • hives (yes, these may happen, but they usually are not serious)

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Interactions

A. Top Drug-Drug Interactions:

1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).

2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.

3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.

Other Drug-Drug interactions:

  • Ketoconazole, itraconazole (used to manage fungal infection)
  • Protease inhibitors (used to manage HIV infection) Ex. ritonavir, lopinavir
  • Phenobarbital, phenytoin, carbamazepine (medicines used for fits)
  • Rifampicin, erythromycin, clarithromycin (medicines used for bacterial infections)
  • Other medicines used to improve blood flow to the penis (Ex. sildenafil)

B. Drug-Food Interactions:

Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:

  1. Grapefruit and Grapefruit Juice: Grapefruit can increase the levels of tadalafil in your blood by interfering with its metabolism. This may amplify side effects, such as headaches, dizziness, or low blood pressure. Avoid consuming grapefruit or grapefruit juice while taking Cialis.
  2. Alcohol: Drinking alcohol with Cialis can enhance the blood pressure-lowering effects of the medication, leading to symptoms like dizziness, lightheadedness, or fainting. Limiting alcohol intake is recommended while using Cialis.
  3. High-Fat Meals: While Cialis can be taken with or without food, consuming it with a high-fat meal may delay its onset of action. Opt for lighter meals if rapid effectiveness is needed.
  4. Caffeine: Though not a direct interaction, combining Cialis with high caffeine intake might worsen side effects like headaches or increase heart rate in sensitive individuals.
Alistams Interactions links to alpha-blockers, which are drugs that cause blood pressure to decrease. These medications work by relaxing blood vessels, leading to an increased blood flow to the penis. Aldactine, a medication used to treat enlarged prostate glands, can amplify the effects of these drugs.See also Warning section.Cialis (tadalafil) can affect the heart. Although not a direct interaction, combining tadalafil with organic nitrates (e.g., nitroglycerin, isosorbide dinitrate) can worsen side effects like headaches, dizziness, or fainting. While not direct interaction, these medications can interfere with the function of the calcium channels in blood vessels. In addition to Cialis, these medications can affect the action of phosphodiesterase type 5 (PDE5), which allows blood to flow more readily to the penis. This may slow down or increase the duration of action of these medications.
  • Other Antibiotics: Similar to tadalafil, foods like grapefruit and grapefruit juice may affect the efficacy of tadalafil.
  • Cialis at costco price at costco

    A generic drug can cost hundreds of dollars, but its maker, Pfizer Inc, has said the price for the drug is $10 per tablet. The company, which has been fighting cheaper generics for years, has said it can lower the price for the drug by between $1 and $5 per tablet.

    Pharmacists say the price has gone up since the drugmaker launched its generic version of Cialis in 2003. The drugmaker, which has more than 8 million prescriptions in the United States, has spent $2.05 billion on the drug in the last five years.

    The generic drugmaker, whose shares have jumped more than 20 percent since the introduction of its own cheaper version of the drug, has raised prices for the brand-name version of the drug from $5 to $10 per tablet, up from a previous high of $11 to $11.50. It will cost about $12, the price of a single tablet.

    Pfizer spokeswoman Heather Bresch said the company's pricing strategy had been "in line with industry trends."

    Cialis is the latest generic drug to price hikes for generics, which have been a mainstay for many big drug companies. But pharma has been raising prices on the drugs since the patent ended last year, and the pharmaceutical industry is already seeing its share price rises.

    The cost of a single pill can make the drug's price so much higher that the maker of the drug can sell off the generic for about 20 years. That could take up to a year, or more, until the patent runs out.

    Pharmacists say they have seen an increase in price since the introduction of the cheaper generic version of Cialis. But they say the price for the brand-name is only a few dollars cheaper than the generic, and that the drugmaker has not raised prices.

    The pharma industry has also been fighting cheaper generics for years, like those used for Cialis, with no success. The generic is sold under the brand name GlaxoSmithKline, which has been fighting to get its version of the drug up to the legal limit of $5 a tablet. The generic is the brand-name version of Eli Lilly and Company.

    A spokeswoman for Pfizer said the company was not making any comments about the cost of its generic until the company submitted its latest patent application in July.

    The company will be offering a cheaper alternative for the drug at a price that is about the same as the generic. The drugmaker said it will offer a cheaper alternative for the brand-name, and that it will only sell the drug for a certain amount, not more.

    The company has been fighting cheaper generics for years.

    Pfizer spokeswoman Bresch said the company's pricing strategy had been "in line with industry trends."

    The company has been fighting cheaper generics for years, like those used for Cialis, with no success.

    Cialis, the second-biggest drug in its class, was the largest drug in the United States in 2007. But the patent for the drug expires in April. The generic is sold as the brand name Eli Lilly, along with Cialis, the brand-name version of Eli Lilly and Company.

    The cost of a single pill can make the drug's price so much higher that the company can sell off the generic for about 20 years.

    As well as its active ingredient, Cialis, is also known for its extended duration of action of up to 36 hours. This duration allows patients to enjoy spontaneous intimacy at the same time. This extended period of effectiveness helps in treating various conditions related to sexual function.

    Cialis is a popular and effective treatment for erectile dysfunction (ED) in men. It is known to be effective in treating symptoms of the condition and helping men get and keep an erection firm enough for sexual intercourse. This is because the active ingredient Tadalafil relaxes the blood vessels in the male genital area and allows for greater blood flow to the area. This improved blood circulation causes the penis to become firm enough for sexual intercourse.

    Cialis can also be used to treat benign prostatic hyperplasia (BPH). This is a condition in which the prostate gland is enlarged and can cause urinary symptoms such as frequent urination, weak stream, and weak urine. However, it is important to note that Cialis does not cure this condition. It helps in improving sexual function by relaxing the blood vessels and allowing the prostate gland to expand. However, it is not a cure-all of the treatment options for ED and will only help improve your overall quality of life.

    It is important to note that Cialis is a phosphodiesterase type 5 (PDE 5) inhibitor. This enzyme is a type of chemical involved in the breakdown of cyclic guanosine monophosphate (cGMP). Cialis inhibits PDE 5, thus, enhancing the levels of cGMP in the body. This results in increased blood flow to the penis. However, it does not cure ED or treat BPH. It will only help you to achieve the best possible erection possible.

    It is not recommended to take Cialis for more than 36 hours before or after sexual activity. This is because Cialis is not a strong inhibitor of PDE 5. This enzyme can break down cGMP, which is responsible for the relaxation of blood vessels. This leads to an increased blood flow to the penis. The increased blood flow results in improved erection. However, this will only help to achieve the best possible erection possible.

    The use of Cialis may lead to side effects such as headache, flushing, nasal congestion, and upset stomach. This is because these effects are due to the increased blood flow to the penis during sexual activity. Some of the common side effects include nausea, dizziness, and flushing. It is essential to be aware of these potential side effects and consult a healthcare professional if they persist or become bothersome. In addition, it is important to note that these side effects are generally temporary and will not cause any major medical problems.

    This is because this is the time when the PDE 5 inhibitor cannot work.